Bronchodilator Responsiveness Following a Negative Methacholine Challenge Test

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Bronchodilator responsiveness following a negative methacholine challenge test.

Asthma is a complex disease of airway inflammation, which results in airway remodeling and hyper-responsiveness.1 Because asthma-related symptoms are not specific to asthma, diagnosis requires objective data from pulmonary function tests (PFT). Bronchodilator responsiveness and airway responsiveness to provocational stimuli (eg, methacholine, dry-gas hyperpnea) help establish the diagnosis of a...

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Assessment of Bronchodilator Responsiveness after Methacholine-Induced Bronchoconstriction

© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Spirometry is the only objective clinical tool available to physicians in the outpatient setting. Patient history is often unreliable and physical examinations are normal when the child doesn’t show symptoms. For that reason, spirometry is...

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Assessment of Bronchodilator Responsiveness Following Methacholine-Induced Bronchoconstriction in Children With Asthma

PURPOSE The aim of this study was to investigate bronchodilator responsiveness (BDR) following methacholine-induced bronchoconstriction and to determine differences in BDR according to clinical parameters in children with asthma. METHODS The methacholine challenge test was performed in 145 children with mild to moderate asthma, and the provocative concentration causing a 20% decline in FEV1 (...

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Methacholine challenge: test-shortening procedures.

STUDY OBJECTIVES Validation of test-shortening procedures for the 2-min tidal breathing methacholine challenge method. DESIGN Retrospective chart review. SETTING Tertiary-care university clinical pulmonary function laboratory. PATIENTS One thousand subjects aged 10 to 85 years (mean +/- SD, 44.5 +/- 16.0 years), 44.5% male, referred for methacholine challenge. INTERVENTION Two-minute ti...

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A positive methacholine challenge test in the absence of symptoms.

A 20-year-old white female nonsmoker presented to the pulmonary function laboratory for a methacholine challenge test. The patient denied wheezing, dyspnea, cough, or chest tightness. In fact, she competes in collegiate basketball and softball without respiratory complaints. She stated that her primary care physician wanted to “screen her for asthma,” because her father is asthmatic. Her medica...

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ژورنال

عنوان ژورنال: Respiratory Care

سال: 2011

ISSN: 0020-1324,1943-3654

DOI: 10.4187/respcare.01031